Organometallic Compounds
Medchemexpress LLC Ph-PEG3 100mg
Ph-PEG3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC Pomalidomide 4'-PEG3-azide | 2271036-46-3 | 96.3% | 100 MG
Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates a Pomalidomide-based cereblon ligand and a linker. It is used for the synthesis of iRucaparib-TP3, a highly efficient PARP1 degrader developed using the PROTAC approach. This compound is also a click chemistry reagent containing an Azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- E3 ligase ligand-linker conjugate
- Incorporates a Pomalidomide-based cereblon ligand
- Utilized for synthesis of iRucaparib-TP3
- Highly efficient PARP1 degrader
- Click chemistry reagent with an azide group
- Enables copper-catalyzed azide-alkyne cycloaddition reactions
- Enables strain-promoted alkyne-azide cycloaddition reactions
Medchemexpress LLC Methyl 2,3-O-isopropylidene-5-O-tosyl-D-ribonucleoside | 4137-56-8 | 99.3% | 358.41 | 5 G
Methyl 2,3-O-isopropylidene-5-O-tosyl-D-ribonucleoside is a biochemical reagent that can be used for compound synthesis. It is for research use only.
- Solid appearance
- White to off-white color
- Ships at room temperature in continental US; may vary elsewhere
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Pomalidomide-PEG3-C2-NH2 TFA | 2414913-97-4 | 99.0% | 1 G
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA)) is a synthetic E3 ligase ligand-linker conjugate composed of a Pomalidomide-based cereblon ligand and a 3-unit PEG linker. It can be utilized for the synthesis of PROTACs. This product is for research use only and not sold to patients.
- Molecular weight: 562.49
- Formula: C23H29F3N4O9
- Appearance: Solid-liquid mixture
- Color: Light yellow to yellow
- Shipping: Room temperature in continental US; may vary elsewhere.
- Storage: 4°C, stored under nitrogen, away from moisture. In solvent: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture).
Medchemexpress LLC BocNH-PEG5-CH2CH2Br 250mg
BocNH-PEG5-CH2CH2Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
Medchemexpress LLC Perfluorophenyl 3-(2-(2-(2-(1,3-dioxoisoindolin-2-yloxy)ethoxy)ethoxy)ethoxy)propanoate | 2101206-87-3 | >96.0% | 533.4 g/mol | C23H20F5NO8 | 10 MG
NHPI-PEG3-C2-Pfp ester is a noncleavable, trifunctional 3-unit polyethylene glycol (PEG) linker bearing an N-hydroxyphthalimide (NHPI) group and a perfluorophenyl (Pfp) activated ester. It is used for bioconjugation and in the synthesis of antibody-drug conjugates (ADCs). Intended for research use only.
- Noncleavable 3-unit PEG linker
- NHPI functional group for site-specific conjugation
- Perfluorophenyl activated ester for amine coupling
- Molecular weight about 533.4 g/mol; formula C23H20F5NO8
- Purity greater than 96%
- Intended for research use only, not for human or animal use
Medchemexpress LLC Beta-D-ribofuranose 1,2,3,5-tetraacetate | 13035-61-5 | MFCD00005358 | 98.0% | 318.28 g·mol⁻¹ | C13H18O9 | 500 G
Beta-D-ribofuranose 1,2,3,5-tetraacetate is an acetylated ribose derivative used as a protected sugar intermediate and biochemical reagent in organic synthesis and life-science research. It is supplied as a solid with documented solubility and formulation data for in vitro and in vivo use.
- Purity 98.0%.
- Molecular weight 318.28 g·mol⁻¹.
- Chemical formula C13H18O9.
- Soluble in DMSO (50 mg/mL; ultrasonic may be required).
- Supplied as a white to off-white solid; available in 500 g and bulk quantities.
Medchemexpress LLC Bcn-peg3-oh | 2126749-77-5 | 99.6% | 369.45 | C19H31NO6 | 10 MG
BCN-PEG3-OH is a BCN-functionalized PEG linker used as a non-cleavable linker and click-chemistry reagent for bioconjugation and antibody-drug conjugate synthesis. It features a BCN group for copper-free strain-promoted alkyne-azide cycloaddition (SPAAC) and a three-unit PEG spacer terminating in a hydroxyl group.
- Non-cleavable PEG linker for ADC synthesis
- BCN group enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Three-unit PEG spacer with terminal hydroxyl
- High purity suitable for research applications
- Available in small pack sizes for laboratory use
Medchemexpress LLC S -2- 2- tert-Buto 1g
(S)-2-(2-((tert-Butoxycarbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanamido)-2-methylpropanoic acid (Boc-his(trt)-aib-ohol) is a drug intermediate for synthesis of various active compounds
![Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl] | 1306615-51-9 | 95.0% | 234.25 g/mol | C8H18N4O4 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000202344.png-250.jpg)
Medchemexpress LLC Hydroxylamine, O-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl] | 1306615-51-9 | 95.0% | 234.25 g/mol | C8H18N4O4 | 100 MG
Aminooxy-PEG3-azide is a PEG-based bifunctional linker containing an aminooxy (hydroxylamine) group and an azide group for orthogonal bioconjugation. It enables oxime formation with aldehydes or ketones and azide-alkyne click chemistry, and is supplied as a liquid at high purity for lab-scale synthesis.
- Contains aminooxy and azide functional groups for orthogonal conjugation
- Enables oxime ligation and azide-alkyne click reactions
- Suitable for ADC, PROTAC, and general bioconjugation workflows
- Supplied as a liquid with high laboratory-grade purity
- Available in small-scale pack sizes for research use
Medchemexpress LLC Azido-PEG3-SSPy | 98.6% | 344.45 g/mol | C13H20N4O3S2 | 25 MG
Azido-PEG3-SSPy is a cleavable three-unit polyethylene glycol (PEG) linker containing an azide functional group, designed for bioconjugation and antibody-drug conjugate (ADC) synthesis. It enables click chemistry (CuAAC) and strain-promoted azide-alkyne cycloadditions (SPAAC) for attachment to alkyne- or DBCO/BCN-containing molecules.
- Cleavable disulfide-containing PEG linker suitable for ADC construction.
- Azide-functionalized for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN.
- Supplied as a colorless to light yellow liquid with high purity.
- Suitable for bioconjugation and linker development in drug conjugates.
![Medchemexpress LLC 1-[4-(3,5-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid | 876625-29-5 | 99.5% | 325.16 g·mol⁻¹ | C16H11Cl2FO2 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000287225.png-250.jpg)
Medchemexpress LLC 1-[4-(3,5-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid | 876625-29-5 | 99.5% | 325.16 g·mol⁻¹ | C16H11Cl2FO2 | 10 MG
This compound is a research-grade small-molecule inhibitor of aldo-keto reductase 1C3 (AKR1C3) that selectively blocks AKR1C3-mediated reduction of doxorubicin and can reverse doxorubicin resistance in AKR1C3-overexpressing cells. Supplied as a high-purity solid, it is intended for biochemical and cellular research applications.
- Target: AKR1C3 inhibitor.
- Mechanism: selectively blocks AKR1C3-mediated reduction of doxorubicin.
- Purity: 99.5% (reported value).
- Physical form: white to off-white solid.
- Solubility: soluble in DMSO (≈100 mg/mL); in vivo formulations reported in DMSO/corn oil.
- Storage: powder stable at -20°C for long-term storage; solutions require low-temperature storage.